The invention relates to a disinfection device (1) for plasma disinfection of surfaces comprising a plasma generator (2) for generating a disinfecting plasma gas stream (PA), and comprising an at least partially closed disinfection area (5) that is in communicating connection with the plasma generator (2), which is configured for receiving the surface (6) to be disinfected. The disinfection device (1) has an aerosol generator (9) for generating an aqueous aerosol stream (A) containing particles. The aerosol generator (9) is in communicating connection with the plasma generator (2) in order to guide the plasma gas stream (PA) mixed with the aerosol stream (A) in the disinfection area (5) onto the surface (6) to be disinfected.