The invention relates to a system for treating surfaces of bodies, in particular a vacuum dressing, comprising at least one attachment means (5a) for fluidic attachment of a negative-pressure generator for generating a negative pressure in a volume that can be positioned at the surface of a body, and at least one means for plasma generation (8, 8a, 15) with which the volume in which the negative pressure can be generated can be at least partially filled with plasma or a plasma-activated medium. The device according to the invention is suitable in particular for combined negative-pressure and plasma therapy of a wound. The invention further relates to a method for treating surfaces of bodies by means of the system according to the invention, wherein a body with a surface to be treated is made available, the system for treating surfaces of bodies is made available, a negative pressure is generated in a volume positioned at the surface of the body, and the volume is at least partially filled with plasma or plasma-activated medium.